A number of facts have been added to the Inquiry into the Effects of Ardent Spirits upon the Body and Mind, and to the Observations upon the Tetanus, Cynanche Trachealis, and Old Age, in the first volume; also to the Observations upon Dropsies, Pulmonary Consumption, and Hydrophobia, contained in the second volume.

The phænomena of fever have not only received a new title, but several new terms have been adopted in detailing them, chiefly to remove the mistake into which the use of Dr. Brown's terms had led some of the author's readers, respecting his principles. A new order has likewise been given, and some new facts added, to the inquiry upon this subject.

In the Account of the Yellow Fever of 1793, many documents, interesting to the public at the time of their first publication, are omitted; and many of the facts and observations, which related to the origin of the fevers of 1794 and 1797, now form a part of a separate inquiry upon that subject, in the fourth volume.