Since the death of Dr. Carroll Dunham, a desire has been expressed by many of his colleagues that his writings should be collected in book form. The present volume contains such as most directly express his views on the cure of disease by drugs. In their arrangement no attention has been paid to the order Of time in which they were written, but those on the principles of cure have been placed together, While clinical cases illustrating these principles have been put side by side; and so great is the unity of thought running through all, that it has not been deemed inappropriate to give to the collection the title of the main Essay.