Apart from its value in treatment, the inoculation has proved itself, as a new instrument of investigation, one of the greatest in the history of research. Nor is it too much to say that by his experimental and comparative methods of using the inoculation M. Pasteur has inaugurated a new epoch in the history of medicine, having in the realm of germ — disease originated amidst the lesions and the dry bones of morbid anatomy a very renaissance itself. His research of rabies is that of a master-mind which has vitally in?uenced and moulded every subsequent investigation of germ disease.