Realizing the close relation existing between anatomy and osteo pathic therapeutics, that the science is built on anatomical and physio logical knowledge, I in 1901 outlined a course in a subject that I chose to call, Applied Anatomy. This book is the outgrowth of that attempt to anatomically explain the signs, cause and treatment of disease. The object of this work is to place osteopathy on a scientific basis by offering anatomical and physiological proof that our etiology of dis ease is correct; to demonstrate that disturbance of function is, as a rule, due to structural changes, and to point out the significance of anatomical changes; and to furnish the practitioner a ready reference for the explain ing of lesions and their effects. Anatomical details have been avoided unless of importance in the explanation of the subject.