All<b> </b>crazy about the Mona Lisa<b> </b>was inspired by a myriad of images on the web on the Mona Lisa. It is interesting to understand this passion that the whole world has towards Mona Lisa. The Mona Lisa was taken up by past and contemporary artists, in design and in various advertising campaigns. Some large companies have based their visual communication on the image of the Mona Lisa and others have transformed their products by taking up the iconography of the Mona Lisa.<br />The aim of this study is to describe the use of the Mona Lisa&#39;s image in art and advertising and at the same time to understand the reasons behind this communicative choice.